The use of hydroxyapatite toothpaste to prevent dental caries

Odontology. 2022 Apr;110(2):223-230. doi: 10.1007/s10266-021-00675-4. Epub 2021 Nov 22.


Dissolution of hydroxyapatite from the tooth structure at low pH can lead to the irreversible destruction of enamel and dentin, which if left untreated can result in pain and tooth loss. Hydroxyapatite toothpastes contain hydroxyapatite particles in micro- or nanocrystalline form that have been shown to deposit and restore demineralized enamel surfaces. As such, they are currently being explored as a fluoride-free anti-caries agent. This narrative review article aims to summarize the recent findings of the research investigating the remineralization potential of HAP toothpaste in vitro, in situ and in vivo, as well as some other applications in dentistry.

Keywords: Enamel; Hydroxyapatite; Oral care; Toothpaste.

Publication types

  • Review

MeSH terms

  • Cariostatic Agents / chemistry
  • Cariostatic Agents / pharmacology
  • Dental Caries* / prevention & control
  • Durapatite / chemistry
  • Fluorides / pharmacology
  • Humans
  • Tooth Remineralization
  • Toothpastes* / chemistry


  • Cariostatic Agents
  • Toothpastes
  • Durapatite
  • Fluorides