We detected Rift Valley fever virus (RVFV) IgM and IgG in human serum samples collected during 2018-2019 in northern KwaZulu-Natal Province, South Africa. Our results show recent RVFV circulation and likely RVFV endemicity in this tropical coastal plain region of South Africa in the absence of apparent clinical disease.
Keywords: Rift Valley fever virus; South Africa; antibodies; cryptic; endemic; humans; mosquitoes; transmission; vector-borne infections; viruses; zoonoses.