Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in kidney disease

Abstract

Matrix metalloproteinases (MMPs) are a group of zinc and calcium endopeptidases which cleave extracellular matrix (ECM) proteins. They are also involved in the degradation of cell surface components and regulate multiple cellular processes, cell to cell interactions, cell proliferation, and cell signaling pathways. MMPs function in close interaction with the endogenous tissue inhibitors of matrix metalloproteinases (TIMPs), both of which regulate cell turnover, modulate various growth factors, and participate in the progression of tissue fibrosis and apoptosis. The multiple roles of MMPs and TIMPs are continuously elucidated in kidney development and repair, as well as in a number of kidney diseases. This chapter focuses on the current findings of the significance of MMPs and TIMPs in a wide range of kidney diseases, whether they result from kidney tissue changes, hemodynamic alterations, tubular epithelial cell apoptosis, inflammation, or fibrosis. In addition, the potential use of these endopeptidases as biomarkers of renal dysfunction and as targets for therapeutic interventions to attenuate kidney disease are also explored in this review.

Keywords: Acute kidney injury; Chronic allograft nephropathy; Chronic kidney disease; Diabetic nephropathy; Glomerulonephritis; Glomerulosclerosis; Hemodialysis; Matrix metalloproteinases; Polycystic kidney disease; Tissue inhibitor of matrix metalloproteinases; Tubulointerstitial fibrosis.