Update on Medical Management of Pulmonary Arterial Hypertension

Cardiol Clin. 2022 Feb;40(1):13-27. doi: 10.1016/j.ccl.2021.08.002.


Pulmonary arterial hypertension is a rare disease characterized by pulmonary microvasculature remodeling leading to right ventricular failure and death. Medical management of pulmonary hypertension has grown increasingly complex as more therapeutic agents have been developed. Evolving treatment strategies leveraging the endothelin, nitric oxide, and prostacyclin pathways lead to improved exercise capacity and outcomes in patients; however, significant opportunities for advancement remain.

Keywords: Medical management; Pulmonary arterial hypertension; Pulmonary hypertension; Therapy; Treatment.

Publication types

  • Review

MeSH terms

  • Antihypertensive Agents / therapeutic use
  • Heart Failure*
  • Humans
  • Hypertension, Pulmonary* / drug therapy
  • Hypertension, Pulmonary* / epidemiology
  • Pulmonary Arterial Hypertension*


  • Antihypertensive Agents