Oral manifestations of congenital Zika virus infection in children with microcephaly: 18-month follow-up case series

Spec Care Dentist. 2022 Jul;42(4):343-351. doi: 10.1111/scd.12681. Epub 2021 Nov 22.

Abstract

Aims: To describe oral manifestations in children born with microcephaly attributed to congenital Zika virus syndrome (CZS).

Methods: Data was collected in semiannual intervals from 2017 to 2019, by oral exams of the children and interview with caregivers at a Public Dental Center in Rio de Janeiro, Brazil. A single calibrated examiner performed clinical examinations.

Results: Of 38 eligible children, 34 were followed-up from 12 to 30 months of age, 20 boys and 14 girls. The mean age of emergence of their first primary tooth was 12.4 months (SD = 2.9). By 30 months of age only 14.7% (n = 5) had complete primary dentition. Alteration in the sequence of tooth emergence was observed in 41.1% (n = 14). Radiographic examination demonstrated dental agenesis (14.7% n = 5). Dental developmental alterations (38.2%, n = 13), enamel defects (14.7%, n = 5), eruption cysts/hematoma (23.5%, n = 8), gingival bleeding (55.8%, n = 19), narrow palate, and bruxism (64.7%, n = 22) were also observed. No child had dental caries.

Conclusion: Children with microcephaly attributed to CZS presented oral manifestations early in life.

Keywords: Zika virus; microcephaly; oral health; tooth abnormalities; tooth eruption.

MeSH terms

  • Adult
  • Brazil / epidemiology
  • Dental Caries*
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Male
  • Microcephaly* / diagnosis
  • Young Adult
  • Zika Virus Infection* / complications
  • Zika Virus Infection* / congenital
  • Zika Virus Infection* / diagnosis
  • Zika Virus*