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. 2022 Feb 1;8(2):300-301.
doi: 10.1001/jamaoncol.2021.6764.

Assessment of Response to a Third Dose of the SARS-CoV-2 BNT162b2 mRNA Vaccine in Patients With Solid Tumors Undergoing Active Treatment

Yakir Rottenberg  1   2 , Albert Grinshpun  3 , Iddo Z Ben-Dov  4   2 , Esther Oiknine Djian  5   2 , Dana G Wolf  5   2 , Luna Kadouri  1   2
Affiliations

Assessment of Response to a Third Dose of the SARS-CoV-2 BNT162b2 mRNA Vaccine in Patients With Solid Tumors Undergoing Active Treatment

Yakir Rottenberg et al. JAMA Oncol. .

Abstract

This cohort study evaluates the short-term humoral response to a third dose of the SARS-CoV-2 BNT162b2 vaccine in patients undergoing acute systemic therapy for solid tumors.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Grinshpun reported support from the Israel Science Foundation (grant 3020/20) and the 2020 Conquer Cancer Israel Cancer Research Fund Career Development Award. Dr Kadouri reported support from Eli Lilly outside the submitted work. No other disclosures were reported.

Figures

Figure.
Figure.. Serologic Response to a Third Dose of the SARS-CoV-2 BNT162b2 mRNA Vaccine in Patients With Cancer Undergoing Active Treatment
Comparison between antibody levels after the second dose and the third booster dose of BNT162b2 (Pfizer-BioNTech) in patients treated with chemotherapy and nonchemotherapy regimens. Measurements less than 12 AU/mL are considered negative, 12 to 19 AU/mL are equivocal, and greater than 19 are positive (dashed line). Levels above 60 AU/mL were shown to be protective. The upper antibody titer limit was capped at more than 400 AU/mL; thus, the titer differences may be higher than those recorded. The titer increment in both groups is statistically significant at P < .001.
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