Objective: To explore the association of maternal anxiety with congenital heart disease (CHD) in offspring. Methods: A case-control study design was used in this study. The data were collected in Shaanxi province from January 2014 to December 2016. Neonatal information is provided through specialized hospitals or institutions. Logistic regression model with adjustment for confounding factors was established to analyze the association between maternal perinatal anxiety and CHD in offspring. Meanwhile, subgroup analysis was carried out to explore its stability. Results: Our study included 2 429 subjects, consisting of 773 cases and 1 656 controls. Women with anxiety during pregnancy accounted for 10.3% in the case group, while 7.8% in the control group. After adjusting for confounding factors, the level of maternal anxiety during pregnancy was positively correlated with CHD in the offspring (OR=1.04, 95%CI: 1.01-1.07). The risk of CHD in the offspring of mothers with anxiety during pregnancy was 1.43 times higher than that in those whose mothers had no anxiety (OR=1.43, 95%CI: 1.00-2.05). Conclusion: Maternal anxiety during pregnancy is probably a risk factor for congenital heart disease in offspring.
目的： 研究母亲围孕期焦虑与子代先天性心脏病（CHD）的关系。 方法： 数据来源于2014年1月至2016年12月在陕西省开展的CHD相关危险因素病例对照研究，通过焦虑自评表对母亲围孕期焦虑情绪进行评分，新生儿相关信息通过专业医院或机构提供。通过调整混杂因素的logistic回归分析母亲围孕期焦虑对新生儿CHD的影响，并进行亚组分析探索其稳定性。 结果： 共纳入2 429例调查对象，病例组773例，对照组1 656例，其中病例组中围孕期焦虑者占10.3%，对照组中围孕期焦虑者占7.8%。在控制混杂因素后，母亲围孕期焦虑得分水平与子代患CHD呈正相关（OR=1.04，95%CI：1.01~1.07），母亲围孕期焦虑者子代发生CHD的风险是无焦虑者的1.43倍（OR=1.43，95%CI：1.00~2.05）。 结论： 母亲围孕期焦虑可能增加子代CHD的风险。.