Dual-Targeting Approach for CD40 and 4-1BB

Cancer Discov. 2022 Jan;12(1):9-10. doi: 10.1158/2159-8290.CD-NB2021-0403. Epub 2021 Nov 23.

Abstract

Preliminary findings from a first-in-human phase I/II trial of GEN1042, a bispecific antibody that simultaneously targets CD40 and 4-1BB on immune cells, suggest that this drug is well tolerated and active in patients with advanced solid tumors.

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  • News