Prolongation of life span of dystrophic hamster by cysteine proteinase inhibitor, loxistation (EST)

J Pharmacobiodyn. 1987 Nov;10(11):678-81. doi: 10.1248/bpb1978.10.678.

Abstract

We studied the effect of loxistation (EST), an orally applicable cysteine proteinase inhibitor, on dystrophic hamsters, UM-X7.1.E-64-c, an active form of EST, was continuously found in plasma when the feed containing EST was given ad libitum. The drug concentration in plasma of dystrophic hamsters receiving EST feed showed distinct dose dependency. A diet containing EST from weaning to death significantly prolonged the survival period of the dystrophic hamsters.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Circadian Rhythm
  • Cricetinae
  • Diet
  • Dose-Response Relationship, Drug
  • Female
  • Leucine / analogs & derivatives*
  • Leucine / blood
  • Leucine / therapeutic use
  • Male
  • Muscular Dystrophy, Animal / drug therapy*
  • Serine Proteinase Inhibitors*

Substances

  • Serine Proteinase Inhibitors
  • Leucine
  • aloxistatin