The brain remembers where and how inflammation struck

Nadine Gogolla

doi:10.1016/j.cell.2021.11.002

The brain remembers where and how inflammation struck

Cell. 2021 Nov 24;184(24):5851-5853. doi: 10.1016/j.cell.2021.11.002.

Author

Nadine Gogolla¹

Affiliation

¹ Circuits for Emotion Research Group, Max Planck Institute of Neurobiology, Martinsried, Germany; Department of Emotion Research, Max Planck Institute of Psychiatry, Munich, Germany. Electronic address: ngogolla@neuro.mpg.de.

PMID: 34822782
DOI: 10.1016/j.cell.2021.11.002

Abstract

Our immune system and brain interact on multiple scales, but how the brain represents and remembers immune challenges remains unclear. In this issue of Cell, Koren et al. (2021) reveal that the brain's insular cortex stores information about inflammation in the body. Strikingly, these immunological "memory engrams" can restore the initial disease state when reactivated.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Brain*
Humans
Immune System
Inflammation
Insular Cortex*