The brain remembers where and how inflammation struck

Cell. 2021 Nov 24;184(24):5851-5853. doi: 10.1016/j.cell.2021.11.002.


Our immune system and brain interact on multiple scales, but how the brain represents and remembers immune challenges remains unclear. In this issue of Cell, Koren et al. (2021) reveal that the brain's insular cortex stores information about inflammation in the body. Strikingly, these immunological "memory engrams" can restore the initial disease state when reactivated.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Brain*
  • Humans
  • Immune System
  • Inflammation
  • Insular Cortex*