Diagnosis and management of premature ovarian insufficiency

Best Pract Res Clin Endocrinol Metab. 2021 Dec;35(6):101600. doi: 10.1016/j.beem.2021.101600. Epub 2021 Nov 16.


Premature ovarian insufficiency (POI) is a complex clinical syndrome with life-changing physiological and psychological consequence in young women of reproductive age. However, the understanding of the etiology, diagnosis and optimal intervention strategies for this condition remains poorly understood. In recent years advances in epidemiologic and genetic research has improved our knowledge and awareness of POI. Further prospective randomised trials are required to improve the psychological and sexual health, fertility treatment options and long-term management of the impact on bone, cardiovascular and cognitive impact in women with POI. In this paper we aim to provide an overview on the diagnosis and management of POI, discuss the current understanding of the condition and future directions.

Keywords: cardiovascular disease; cognitive health; estrogen-deficiency; hormone replacement therapy; premature ovarian insufficiency; reproductive health.

Publication types

  • Review

MeSH terms

  • Female
  • Humans
  • Primary Ovarian Insufficiency* / diagnosis
  • Primary Ovarian Insufficiency* / etiology
  • Primary Ovarian Insufficiency* / therapy