Can dietary intake protect against low-grade inflammation in children and adolescents?

Brain Behav Immun Health. 2021 Oct 28;18:100369. doi: 10.1016/j.bbih.2021.100369. eCollection 2021 Dec.


In children and adolescents, chronic low-grade inflammation has been implicated in the pathogenesis of co- and multi-morbid conditions to mental health disorders. Diet quality is a potential mechanism of action that can exacerbate or ameliorate low-grade inflammation; however, the exact way dietary intake can regulate the immune response in children and adolescents is still to be fully understood. In this review, I discuss the current observational and interventional evidence that supports a potential therapeutic role for dietary intake in the amelioration of low-grade inflammation and highlight the need to develop a better understanding of the biological mechanisms underlying and attenuating the associations between dietary intake and low-grade inflammation in children and adolescents.

Keywords: Adolescent; Biomarkers; CRP; Children; Cytokine; Dietary intake; Dietary pattern; Inflammation; Interleukin; Macronutrients.

Publication types

  • Review