Epidemiology, clinical profile and treatment outcomes of bacterial and fungal keratitis

Int Ophthalmol. 2022 May;42(5):1401-1407. doi: 10.1007/s10792-021-02128-x. Epub 2021 Nov 28.


Purpose: The purpose of the study is to determine the microbiological etiology, epidemiological factors, and clinical profile and treatment outcomes of infective keratitis in Ophthalmology department, Minia University, Egypt.

Methods: Prospective, nonrandomized, observational clinical series of cases, including 150 patients with mean age 30 (range 12 to 85 years), 90 patients (60%) were males and 60 (40%) were females, clinically diagnosed as infective corneal ulcer, attending the Ophthalmology Department-Faculty of Medicine. Minia University, Minia, Egypt. From December 2018 to December 2020. Detailed history taking and all clinical findings were collected. Corneal scrapings were obtained from patients and subjected to staining and culture for bacterial and fungal pathogens; Bacterial and fungal growth were identified by standard laboratory procedures.

Results: Corneal trauma by a vegetative matter was the commonest risk factor associated with infective keratitis in 92 cases (61.3%). Smear and culture was positive in 83 cases (58.4%) of 142 corneal scrapings obtained, of which 60 cases were fungal (72.3%), 21 cases were bacterial (25.3%) and two cases were mixed bacterial and fungal (2.4%), Aspergillus species was the commonest fungal species isolated in fungal keratitis. One hundred forty-two cases (94.67%) healed completely with scar. Only six cases (4%) required evisceration due to aggressive presentation from the start and keratoplasty was performed for two cases (1.33%).

Conclusions: Fungal keratitis was the commonest type in cases attending to our department. Adequate diagnosis, management and follow-up helped in achieving high successful curative outcomes.

Clinical trial number: Clinical Trials.gov ID: NCT04894630. Time of registration 1 December 2018.

Keywords: Bacterial keratitis; Corneal trauma; Fungal keratitis.

Publication types

  • Observational Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Bacteria
  • Child
  • Corneal Ulcer* / diagnosis
  • Corneal Ulcer* / epidemiology
  • Corneal Ulcer* / therapy
  • Eye Infections, Fungal* / diagnosis
  • Eye Infections, Fungal* / epidemiology
  • Eye Infections, Fungal* / therapy
  • Female
  • Humans
  • Keratitis* / diagnosis
  • Keratitis* / epidemiology
  • Keratitis* / therapy
  • Male
  • Middle Aged
  • Prospective Studies
  • Retrospective Studies
  • Treatment Outcome
  • Young Adult

Associated data

  • ClinicalTrials.gov/NCT04894630