A 33-year-old woman developed palindromic rheumatism (PLR) several weeks following an infection with severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2). Three months later, she developed full blown seropositive rheumatoid arthritis (RA) following COVID-19 reinfection. Although the occurrence of the joint diseases and the COVID-19 infections maybe fortuitous, knowing the enormous effects of COVID-19 infection on the human immune system, it is difficult to ignore the temporal relationship between the appearance of PLR after the first COVID-19 infection and the transition to full blown RA following her COVID-19 re-infection.