Nutrigenetics and nutrigenomics-A personalized approach to nutrition

Adv Genet. 2021:108:277-340. doi: 10.1016/bs.adgen.2021.08.005. Epub 2021 Oct 28.


The prevalence of non-communicable diseases has been on an upward trajectory for some time and this puts an enormous burden on the healthcare expenditure. Lifestyle modifications including dietary interventions hold an immense promise to manage and prevent these diseases. Recent advances in genomic research provide evidence that focussing these efforts on individual variations in abilities to metabolize nutrients (nutrigenetics) and exploring the role of dietary compounds on gene expression (nutrigenomics and nutri-epigenomics) can lead to more meaningful personalized dietary strategies to promote optimal health. This chapter aims to provide examples on these gene-diet interactions at multiple levels to support the need of embedding targeted dietary interventions as a way forward to prevent, avoid and manage diseases.

Keywords: Dietary bioactive compounds; Epigenetics; Gene-diet interactions; Genome; Nutraceuticals; Nutrigenetics; Nutrigenomics; Obesity; Polymorphisms.

MeSH terms

  • Epigenomics*
  • Gene Expression
  • Nutrigenomics*