Host factors and vaccine efficacy: Implications for COVID-19 vaccines

J Med Virol. 2022 Apr;94(4):1330-1335. doi: 10.1002/jmv.27485. Epub 2021 Dec 7.

Abstract

The efficacy of the vaccines varies between individuals and populations. The immunogenicity of the vaccine is influenced by various factors, including host factors. Previous studies have shown that host factors affect the effectiveness of vaccines, which may be true about COVID-19 vaccines. In this review, we evaluate the possible association of host factors with vaccine efficacy with a special focus on COVID-19 vaccines.

Keywords: COVID-19; COVID-19 vaccine; SARS-CoV-2; host factors; vaccine efficacy; vaccine immunogenicity.

Publication types

  • Review

MeSH terms

  • Age Factors
  • Body Mass Index
  • COVID-19 / immunology
  • COVID-19 / prevention & control
  • COVID-19 / virology
  • COVID-19 Vaccines / immunology*
  • Gastrointestinal Microbiome
  • Humans
  • Immunity
  • Immunogenicity, Vaccine
  • Nutritional Status / immunology
  • Obesity / immunology
  • Polymorphism, Genetic
  • SARS-CoV-2 / genetics
  • SARS-CoV-2 / immunology
  • Sex Factors
  • Vaccine Efficacy*

Substances

  • COVID-19 Vaccines