Live birth after in vitro maturation in women with gonadotropin resistance ovary syndrome: report of two cases

J Assist Reprod Genet. 2021 Dec;38(12):3243-3249. doi: 10.1007/s10815-021-02355-2. Epub 2021 Nov 30.


Purpose: Gonadotropin-resistant ovary syndrome (GROS) is a rare endocrine disorder that causes hypergonadotropic hypogonadism, amenorrhea, and infertility. This study reports live birth in two women with GROS who underwent fertility treatment with in vitro maturation (IVM).

Methods: Both patients had primary infertility, amenorrhea (primary and secondary), typical secondary sexual characters, elevated gonadotropin levels, normal ovarian reserve, normal chromosomal characteristics, and previous nonresponsiveness gonadotropin stimulations. One patient had polymorphism of the follicle-stimulating hormone receptor, which is a predictor of poor ovarian response. Given unresponsiveness to exogenous gonadotropin stimulations, IVM with human chorionic gonadotropin priming (hCG-IVM) was performed in both patients. All transferrable embryos were vitrified.

Results: Both patients achieved pregnancy after their first frozen embryos transfer, and each delivered a healthy baby boy.

Conclusions: These results suggest that IVM should be a first-line therapeutic option for patients with GROS.

Keywords: Gonadotropin-resistant ovary syndrome; In vitro maturation; Infertility; Live birth.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Chorionic Gonadotropin / metabolism*
  • Embryo Transfer / methods
  • Female
  • Fertilization in Vitro / methods
  • Humans
  • In Vitro Oocyte Maturation Techniques / methods
  • Infertility, Female / metabolism
  • Infertility, Female / physiopathology*
  • Live Birth
  • Ovary / metabolism
  • Ovary / physiology*
  • Pregnancy
  • Pregnancy, Multiple / metabolism
  • Pregnancy, Multiple / physiology
  • Primary Ovarian Insufficiency / metabolism
  • Primary Ovarian Insufficiency / physiopathology*
  • Receptors, FSH / metabolism


  • Chorionic Gonadotropin
  • Receptors, FSH