Increased odds ratio for erectile dysfunction in COVID-19 patients

J Endocrinol Invest. 2022 Apr;45(4):859-864. doi: 10.1007/s40618-021-01717-y. Epub 2021 Nov 30.


Purpose: Erectile dysfunction and COVID-19 share similar risk factors, including vascular disruption of integrity, cytokine release, cardiovascular disease, diabetes and obesity. The aim of this study was to investigate the association between erectile dysfunction and COVID-19 patients.

Methods: Odds ratio for erectile dysfunction in patients with a history of COVID-19 with and without comorbidities were calculated using a patients' registry platform i2b2. ICD-10 diagnoses codes were accessed for queries and data were analyzed using logistic regression.

Results: Patients with COVID-19 were 3.3 times more likely to have erectile dysfunction with 95% CI (2.8, 3.8). The association became stronger with odds ratio 4.8 (95% CI (4.1, 5.7)) after adjusting for age groups. The odds ratio remained the same after adjusting for smoking status with 3.5 (95% CI (3.0, 4.1)). After adjusting for race, COVID-19 patients were 2.6 (95% CI (2.2, 3.1)) times more likely to have erectile dysfunction. The odds ratio were 1.6, 1.8, 1.9 and 2.3 after adjusting for respiratory disease, obesity, circulatory disease and diabetes, respectively.

Conclusion: COVID-19 and erectile dysfunction are strongly associated even after adjustment for known risk factors and demographics.

Keywords: COVID-19; Endothelial disruption; Erectile dysfunction; Odds ratio.

MeSH terms

  • Adult
  • Aged
  • COVID-19 / complications
  • COVID-19 / epidemiology*
  • Comorbidity
  • Erectile Dysfunction / epidemiology*
  • Erectile Dysfunction / etiology
  • Humans
  • Male
  • Middle Aged
  • Odds Ratio
  • Prevalence
  • Risk Factors