Reactivation of IgA vasculitis following COVID-19 vaccination

BMJ Case Rep. 2021 Nov 30;14(11):e247188. doi: 10.1136/bcr-2021-247188.


A 23-year-old man presented to the acute assessment unit with acute-onset haematuria within 24 hours of receiving his second dose of the Pfizer-BioNTech COVID-19 vaccine. He had been diagnosed with IgA vasculitis 8 months previously. IgA vasculitis is an autoimmune condition characterised by palpable purpura affecting the lower limbs, abdominal pain, arthralgia and renal disease. He was diagnosed with an acute exacerbation of IgA vasculitis and was discharged with oral prednisolone. Reactivation or first presentation of IgA vasculitis is a rare but increasingly recognised complication of COVID-19 vaccination. This is an important new differential in the assessment of patients with haematuria following COVID-19 vaccination.

Keywords: haematuria; proteinuria; renal medicine; vasculitis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • COVID-19 Vaccines
  • COVID-19*
  • Humans
  • Male
  • SARS-CoV-2
  • Vaccination
  • Young Adult


  • COVID-19 Vaccines