Association between BoLA-DRB3 polymorphism and bovine leukemia virus proviral load in Vietnamese Holstein Friesian cattle

HLA. 2022 Feb;99(2):105-112. doi: 10.1111/tan.14503. Epub 2022 Jan 5.


Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leukosis. Polymorphism in bovine leukocyte antigen (BoLA)-DRB3 allele can influence the host immune response to pathogens, including BLV. However, association between specific BoLA-DRB3 alleles and BLV proviral load (PVL), which is a useful index for estimating disease progression and transmission risk, in Vietnamese cattle are unknown. Here, association study of BoLA-DRB3 allele frequency between cattle with high or low PVL demonstrated BoLA-DRB3*12:01 associates with high PVL in Vietnamese Holstein Friesian (HF) crossbred cattle. This is the first study to demonstrate that BoLA-DRB3 polymorphism confers susceptibility to BLV high PVL in HF crossbred kept in Vietnam. Our results may be useful in disease control and eradiation for BLV through genetic selection.

Keywords: BoLA-DRB3; Vietnamese dairy cattle; bovine leukemia virus; proviral load; susceptibility.

MeSH terms

  • Alleles
  • Animals
  • Cattle* / genetics
  • Histocompatibility Antigens Class II / genetics
  • Leukemia Virus, Bovine* / genetics
  • Proviruses / genetics
  • Vietnam
  • Viral Load / veterinary


  • BoLA-DRB3 antigen
  • Histocompatibility Antigens Class II