Excessive mitophagy for anxiety

Hongsheng Wang; Wen-Cheng Xiong; Lin Mei

doi:10.1016/j.neuron.2021.11.007

Excessive mitophagy for anxiety

Neuron. 2021 Dec 1;109(23):3715-3716. doi: 10.1016/j.neuron.2021.11.007.

Authors

Hongsheng Wang¹, Wen-Cheng Xiong¹, Lin Mei²

Affiliations

¹ Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106, USA.
² Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106, USA. Electronic address: lin.mei@case.edu.

PMID: 34856130
DOI: 10.1016/j.neuron.2021.11.007

Abstract

In this issue of Neuron, Duan et al. (2021) identified excessive mitophagy in BLA neurons synapsing onto adBNST neurons as a mechanism for reduced neurotransmission and social defeat-induced anxiety-like behaviors.

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MeSH terms

Anxiety Disorders
Anxiety*
Humans
Mitophagy*
Neurons
Synaptic Transmission