Severe neonatal autoimmune thrombocytopenia secondary to maternal Evans syndrome

BMJ Case Rep. 2021 Dec 2;14(12):e245695. doi: 10.1136/bcr-2021-245695.


Evans syndrome is a rare and chronic autoimmune disease seen in both paediatric and adult age groups. We present a case of severe thrombocytopenia in a neonate born to a mother with Evans syndrome who showed no response to intravenous immunoglobulin therapy initially and improved after treatment with methylprednisolone.

Keywords: haematology (incl blood transfusion); materno-fetal medicine; neonatal and paediatric intensive care; neonatal intensive care.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anemia, Hemolytic, Autoimmune* / complications
  • Anemia, Hemolytic, Autoimmune* / diagnosis
  • Anemia, Hemolytic, Autoimmune* / drug therapy
  • Child
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use
  • Infant, Newborn
  • Purpura, Thrombocytopenic, Idiopathic* / complications
  • Purpura, Thrombocytopenic, Idiopathic* / diagnosis
  • Purpura, Thrombocytopenic, Idiopathic* / drug therapy
  • Thrombocytopenia
  • Thrombocytopenia, Neonatal Alloimmune*


  • Immunoglobulins, Intravenous

Supplementary concepts

  • Evans Syndrome