Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Mar;74(3):419-428.
doi: 10.1111/lam.13622. Epub 2021 Dec 14.

Biological activity of roots and aerial parts of Zinnia peruviana on pathogenic micro-organisms in planktonic state and biofilm forming

Affiliations

Biological activity of roots and aerial parts of Zinnia peruviana on pathogenic micro-organisms in planktonic state and biofilm forming

A M Mohamed et al. Lett Appl Microbiol. 2022 Mar.

Abstract

Microbial resistance to antibiotics affects the control of clinical infections and is a growing concern in global public health. One important mechanism whereby micro-organisms acquire resistance is biofilm formation. This context has led to the investigation of new antimicrobial substances from plants popularly used in folk medicine. In this work, we studied the antimicrobial and antibiofilm activity of Zinnia peruviana roots, ziniolide (major root metabolite) and aerial parts against Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, Escherichia coli, Pseudomonas aeruginosa and Candida albicans. The minimum inhibitory and minimum microbicidal concentration and inhibition of biofilm production was determined. All Z. peruviana extracts showed antimicrobial activity, but that corresponding to the roots was the most active one. The best inhibitory and microbicidal activity was detected against Gram-positive bacteria (0·039-0·078 mg ml-1 ). The acetonic extract from Z. peruviana leaves showed moderate activity against Gram-positive bacteria (0·625 mg ml-1 ). Acetonic extract of Z. peruviana flowers showed weak activity (1·25-5 mg ml-1 ). All the extracts tested showed inhibition of biofilm formation, as well as the ziniolide, however, roots and flowers extracts showed higher antibiofilm activity particularly against Staphylococcus, Listeria and Candida. The extracts tested may be a promising natural alternative for the control of microbial infections.

Keywords: Zinnia peruviana; biofilm; biological activity; planktonic state; ziniolide.

PubMed Disclaimer

Similar articles

References

    1. Ahmad Khan, M.S., Alshehrei, F., Al-Ghamdi, S.B., Bamaga, M.A., Al-Thubiani, A.S. and Alam, M.Z. (2020) Virulence and biofilms as promising targets in developing antipathogenic drugs against candidiasis. Future Sci OA 6, FSO440.
    1. Asmerom, D., Hailu, G.S., Yimer, E.M., Bitew, H. and Kahsay, G. (2020) Antimicrobial evaluation of latex and TLC fractions from the leaves of Aloe adigratana reynolds. J Evid Based Complementary Altern Med 2020, 1-10.
    1. Bader, A., Giner, R.M., Martini, F., Schinella, G.R., Ríos, J.L., Braca, A. and Prieto, J.M. (2013) Modulation of COX, LOX and NFκB activities by Xanthium spinosum L. root extract and ziniolide. Fitoterapia 91, 284-289.
    1. Bahraminejad, S., Abbasi, S. and Amiri, R. (2015) The effect of some medicinal and ornamental plant extracts against Fusarium oxysporum. J Crop Protec 4, 189-197.
    1. Barboza, G.E., Cantero, J.J., Núñez, C., Pacciaroni, A. and Espinar, L.A. (2009) Medicinal plants: a general review and a phytochemical and ethnopharmacological screening of the native Argentine Flora. Kurtziana 34, 1-20.