Accurate and predictive lesion-symptoms mapping is a major goal in the field of clinical neurosciences. Recent studies have called for a reappraisal of the results given by the standard univariate voxel-based lesion-symptom mapping technique, emphasizing the need of developing multivariate methods. While the organization of large datasets and their analysis with machine learning (ML) approaches represents an opportunity to increase prediction accuracy, the complexity and dimensionality of the problem remain a major obstacle. Acknowledging the difficulty of inferring individual outcomes from the observation of spatial patterns of lesions, we propose here to base prediction on new individuals on models of brain connectivity, whereby the disruption of a given network predicts the occurrence of selective deficits. Well-suited ML tools are necessary to capture the relevant information from limited datasets and perform reliable inference.
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