Chaperone networks are shaped by cellular differentiation and identity

Khairun Nisaa; Anat Ben-Zvi

doi:10.1016/j.tcb.2021.11.001

Chaperone networks are shaped by cellular differentiation and identity

Trends Cell Biol. 2022 Jun;32(6):470-474. doi: 10.1016/j.tcb.2021.11.001. Epub 2021 Dec 1.

Authors

Khairun Nisaa¹, Anat Ben-Zvi²

Affiliations

¹ Department of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
² Department of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel. Electronic address: anatbz@bgu.ac.il.

PMID: 34863585
DOI: 10.1016/j.tcb.2021.11.001

Abstract

Chaperone expression is developmentally regulated, establishing tissue-specific networks. However, the molecular basis underlying this specificity is mainly unknown. Recent evidence suggests that chaperone network rewiring is mediated, in part, by differentiation transcription factors to fit the proteome folding demands, with implications for the tissue-specific manifestation of protein misfolding diseases.

Keywords: chaperone; differentiation; proteostasis; stress.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Differentiation
Humans
Molecular Chaperones* / metabolism
Protein Folding
Proteome / metabolism
Proteostasis Deficiencies* / metabolism
Transcription Factors

Substances

Molecular Chaperones
Proteome
Transcription Factors