The Use of Oligo Fucoidan in Cancer Bearing Dogs Undergoing Chemotherapy: A Double-Blinded Study

Top Companion Anim Med. 2022 Jan-Feb:46:100616. doi: 10.1016/j.tcam.2021.100616. Epub 2021 Dec 2.


We evaluated the effect of oligo fucoidan (Laminina Japonica) derived from oceanic brown seaweed on the quality of life in dogs with cancer undergoing chemotherapy in a double-blinded case control study. Included in this prospective study were 100 dogs with a confirmed diagnosis of cancer that were being treated with chemotherapy. Dogs were randomly assigned to be treated with oligo fucoidan (treated group; n = 68) or placebo (placebo group; n = 32). Dogs were evaluated every 2-3 weeks for 3 months with a complete blood count (CBC) and serum biochemistry profile, and a complete history and physical examination by blinded clinicians at The Veterinary Cancer Center. The owners of the dogs enrolled in the study were required at each visit to complete a Quality-of-Life Questionnaire specifically designed for cancer-bearing veterinary patients. The owners were also blinded as to whether their dog was receiving oligo fucoidan or placebo. There were no significant differences between the CBC parameters or the serum biochemical parameters of the dogs in the treated and placebo-controlled groups. There was no significant difference in the median quality of life scores between the 2 cohorts, however, when evaluating the individual quality of life metrics, 5 out of the 23 metrics showed statistically significant improvement, and none of the quality-of-life metrics declined in the oligo fucoidan group as compared to the placebo group. All of the dogs that had a positive change in overall quality of life scores were dogs that received oligo fucoidan. There were minimal adverse side effects of giving the oligo fucoidan to dogs. Treatment with oligo fucoidan was safe and improved some of the quality-of-life metrics in dogs who were being treated with chemotherapy for cancer.

Keywords: canine cancer; chemotherapy; double-blinded study; fucoidan; oligo fucoidan; quality of life.

Publication types

  • Randomized Controlled Trial, Veterinary

MeSH terms

  • Animals
  • Antineoplastic Agents* / therapeutic use
  • Case-Control Studies
  • Dog Diseases* / drug therapy
  • Dogs
  • Neoplasms* / drug therapy
  • Neoplasms* / veterinary
  • Polysaccharides
  • Prospective Studies
  • Quality of Life


  • Antineoplastic Agents
  • Polysaccharides
  • fucoidan