Cardiovascular effects of positive end-expiratory pressure in dogs

J Appl Physiol Respir Environ Exerc Physiol. 1978 May;44(5):743-50. doi: 10.1152/jappl.1978.44.5.743.


Our purpose was to reexamine the relationship of the fall in cardiac output and blood pressure which occurs during positive end-expiratory pressure (PEEP) to changes in transmural right atrial and left atrial filling pressures. Closed-chest dogs, half with pulmonary edema, were studied during spontaneous breathing and inspiratory positive-pressure breathing (IPPB) with 0-15 cmH2O PEEP. Mean esophageal pressure accurately reflected changes in pericardial pressure and was used to estimate extracardiac pressure. We found that cardiac output fell approximately 50% and blood pressure fell 20% during 15 cmH2OPEEP in spite of well maintained transmural right atrial and left atrial (or pulmonary artery wedge) pressures suggesting a primary or reflex depression of atrial or ventricular function.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anesthesia
  • Animals
  • Atrial Function
  • Blood Pressure*
  • Cardiac Output*
  • Cardiovascular Physiological Phenomena*
  • Dogs
  • Esophagus / blood supply
  • Heart Rate
  • Intermittent Positive-Pressure Breathing
  • Models, Biological
  • Pericardium / physiology
  • Positive-Pressure Respiration / adverse effects*
  • Pulmonary Artery
  • Pulmonary Edema / physiopathology
  • Pulmonary Edema / therapy