Diversity, rearrangement, and expression of murine T cell gamma genes

Cell. 1986 Jun 6;45(5):733-42. doi: 10.1016/0092-8674(86)90787-7.


Although the T cell gamma genes are similar in many respects to T cell receptor alpha and beta genes, earlier studies suggested that only a single gamma variable (V gamma) gene is expressed in mature T cells. We report the isolation and characterization of three new rearranged V gamma genes from murine fetal thymocytes. Although each of the new V gamma gene rearrangements is present in fetal thymocytes, two of them are undetectable in mature T cells. The levels of mRNA corresponding to each type of V gamma gene rearrangement in mature T cells are dramatically diminished compared with those in fetal thymocytes, although the abundance of two of the rearranged genes is increased in mature T cells. Our results demonstrate that there is significant expressed variability of gamma genes in immature T cells. Furthermore, the dynamics of gamma gene rearrangement and expression support the idea that gamma genes function in immature T cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Differentiation
  • Cloning, Molecular
  • Gene Expression Regulation
  • Genes
  • Lymphocyte Activation
  • Mice
  • Mice, Inbred BALB C
  • RNA, Messenger / analysis
  • Receptors, Antigen, T-Cell / genetics*
  • Sequence Homology, Nucleic Acid
  • T-Lymphocytes / analysis*
  • Thymus Gland / analysis


  • RNA, Messenger
  • Receptors, Antigen, T-Cell

Associated data

  • GENBANK/M13335
  • GENBANK/M13336
  • GENBANK/M13337
  • GENBANK/M13338
  • GENBANK/M13339
  • GENBANK/M13340
  • GENBANK/M13341
  • GENBANK/M13342