Efficacy and safety of sterilisation procedures to reduce the risk of epithelial ovarian cancer: a systematic review comparing salpingectomy with tubal ligation

Eur J Contracept Reprod Health Care. 2022 Jun;27(3):230-239. doi: 10.1080/13625187.2021.2010041. Epub 2021 Dec 6.


Purpose: The objective of this systematic review is to evaluate current literature comparing salpingectomy for sterilisation with tubal ligation, regarding the effectiveness and safety, and assess the certainty of evidence.

Materials and methods: PubMed, Cochrane, and Embase databases were searched. Randomised (RCT) and observational studies were included. Articles were quality assessed and data extracted by two independent authors. Certainty of evidence was assessed using GRADE.

Results: Of 2020 articles, 17 were included. No study investigated the risk of EOC. No difference in anti-Müllerian hormone was reported in one RCT at caesarean section (CS). Two cohort studies evaluated ovarian function with surrogate measures and found no difference at caesarean section. Complications did not differ but were inconsistently reported. Laparoscopic tubal ligation was 7 min faster (95% CI 3.8-10.5). Operative time at caesarean section was dependent on the use of surgical devices. Certainty of evidence was low or very low for all estimates, indicating knowledge gaps. Reliable safety data on salpingectomy for sterilisation is lacking, and there is no effectiveness data. Presently, women cannot be properly counselled regarding salpingectomy for sterilisation.

Keywords: Sterilisation; ovarian cancer; salpingectomy; systematic review; tubal ligation.

Publication types

  • Systematic Review

MeSH terms

  • Carcinoma, Ovarian Epithelial
  • Cesarean Section
  • Female
  • Humans
  • Ovarian Neoplasms* / prevention & control
  • Ovarian Neoplasms* / surgery
  • Pregnancy
  • Salpingectomy / methods
  • Sterilization
  • Sterilization, Tubal* / methods