Serendipity Reveals the Function and Physiological Role of a Large Family of Proteins

J Bacteriol. 2022 Feb 15;204(2):e0055621. doi: 10.1128/JB.00556-21. Epub 2021 Dec 6.


Microbial metabolism involves a complex set of interactions between metabolic pathways that include proteins of both known and uncharacterized function. While investigating the physiological strategy used by actinomycetes with two RpoB paralogs, Damiano et al. uncovered the endonuclease activity of a member of the Rid family (F. Damiano, M. Calcagnile, D. Pasanisi, A. Talà, et al., J Bacteriol, 204:e00462-21, 2022, While this finding was peripheral to the original question posed by the authors, it has considerable significance. The study by Damiano et al. highlights how unexpected, but fundamental, information can be gained by following phenotypic leads.

Keywords: Rid family; RpoB.

Publication types

  • Research Support, N.I.H., Extramural
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