Hemiparkinsonism in monkeys after unilateral internal carotid artery infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

Life Sci. 1986 Jul 7;39(1):7-16. doi: 10.1016/0024-3205(86)90431-5.


Infusion of MPTP (0.2-0.8 mg/kg) into the right internal carotid artery of monkeys produces toxin-induced injury to the right nigrostriatal pathway with sparing of other dopaminergic neurones on the infused side and with negligible or little injury to the opposite, untreated side. There are contralateral limb dystonic postures, rigidity, and bradykinesia, but the animals are able to eat and maintain health without drug treatment. Spontaneous motor activity is attended by circling towards the injured side, whereas treatment with L-DOPA/-carbidopa or apomorphine stimulates circling towards the intact side. Dopamine and dopamine metabolite levels are normal in the left caudate and putamen, but markedly depressed on the right (MPTP-treated) side. This animal hemiparkinsonian model will be useful in studies of volitional movement control, drug treatments of Parkinson's disease, and functional efficacy of brain tissue implants.

MeSH terms

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Animals
  • Apomorphine / pharmacology
  • Brain / pathology
  • Brain Chemistry
  • Carbidopa / pharmacology
  • Carotid Artery, Internal
  • Disease Models, Animal / chemically induced*
  • Disease Models, Animal / pathology
  • Dominance, Cerebral
  • Dopamine / analysis
  • Homovanillic Acid / analysis
  • Injections, Intra-Arterial
  • Levodopa / pharmacology
  • Macaca fascicularis
  • Movement / drug effects
  • Neurons / pathology
  • Parkinson Disease, Secondary / chemically induced*
  • Parkinson Disease, Secondary / pathology
  • Pyridines / toxicity*


  • Pyridines
  • Levodopa
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Carbidopa
  • Apomorphine
  • Dopamine
  • Homovanillic Acid