Increased frequency of idiopathic central precocious puberty in girls during the COVID-19 pandemic: preliminary results of a tertiary center study

J Pediatr Endocrinol Metab. 2021 Dec 8;35(2):249-251. doi: 10.1515/jpem-2021-0565. Print 2022 Feb 23.


Objectives: Recent studies have demonstrated an increase in the frequency of idiopathic central precocious puberty (CPP) during the severe acute respiratory syndrome coronavirus 2 (COVID-19) pandemic. We compared the demographic, anthropometric, and clinical characteristics of idiopathic CPP patients diagnosed during a one-year period of the COVID-19 pandemic with the characteristics of patients diagnosed during the same period in the previous three-years.

Methods: Demographic, clinical, anthropometric, and laboratory data of all patients diagnosed in our Pediatric Endocrinology clinic with idiopathic CPP during a one-year period of the COVID-19 pandemic (April 2020-March 2021) and a three-year period before the pandemic (April 2017-March 2020) were evaluated retrospectively.

Results: A total of 124 patients (124 girls, zero boys) diagnosed with idiopathic CPP were included in this study. Sixty-six patients in the three-year period before the COVID-19 pandemic (April 2017-March 2020) and 58 patients (46.8%) in the one-year period during the COVID-19 pandemic period (April 2020-March 2021) were diagnosed with idiopathic CPP.

Conclusions: This study's findings suggest that the number of girls diagnosed with idiopathic CPP during the one-year study period during the pandemic was more than double that of any of the previous three-years.

Keywords: COVID-19; central precocious puberty (CPP); pandemic.

MeSH terms

  • Age Determination by Skeleton
  • Body Mass Index
  • Body Weight
  • COVID-19*
  • Child
  • Female
  • Humans
  • Pandemics*
  • Puberty, Precocious / epidemiology*
  • Puberty, Precocious / etiology
  • Retrospective Studies