Primary biliary cirrhosis and rheumatic diseases: a clinical, immunological and immunogenetical study

Clin Exp Rheumatol. Apr-Jun 1986;4(2):129-34.


Clinical investigation of Primary Biliary Cirrhosis (PBC) patients showed an elevated frequency of rheumatic disorders, as well as their frequent appearance in asymptomatic PBC. Anticentromere region antibodies in PBC patients were pathognomonic for concomitant complete or incomplete CREST syndrome. These antibodies were only found on the HEp2 cell substrate. The constant finding of immune-complexes (IC) with IgM antibody component suggests that they play a role in the pathogenesis of PBC. No statistically significant correlation was found between the amount and classes of circulating IC, HLA class I antigens and rheumatic disorders during PBC.

MeSH terms

  • Adult
  • Aged
  • Antigen-Antibody Complex / analysis
  • Cryoglobulinemia / complications
  • Female
  • HLA Antigens / analysis
  • HLA Antigens / classification
  • Humans
  • Immunogenetics
  • Immunoglobulins / immunology
  • Liver Cirrhosis, Biliary / complications*
  • Liver Cirrhosis, Biliary / genetics
  • Liver Cirrhosis, Biliary / immunology
  • Male
  • Middle Aged
  • Rheumatic Diseases / complications*
  • Rheumatic Diseases / genetics
  • Rheumatic Diseases / immunology


  • Antigen-Antibody Complex
  • HLA Antigens
  • Immunoglobulins