Gut symbionts dial up RA to prime host defense

Jitender Yadav; Nayanan Nathan; Dana J Philpott

doi:10.1016/j.chom.2021.11.011

Gut symbionts dial up RA to prime host defense

Cell Host Microbe. 2021 Dec 8;29(12):1727-1729. doi: 10.1016/j.chom.2021.11.011.

Authors

Jitender Yadav¹, Nayanan Nathan¹, Dana J Philpott²

Affiliations

¹ Department of Immunology, Medical Sciences Building, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.
² Department of Immunology, Medical Sciences Building, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada. Electronic address: dana.philpott@utoronto.ca.

PMID: 34883060
DOI: 10.1016/j.chom.2021.11.011

Abstract

In this issue of Cell Host & Microbe, Woo et al. (2021) show that retinoic acid generated by symbiotic segmented filamentous bacteria in the intestine primes host intestinal epithelial defense and mediates early innate immune protection against Citrobacter rodentium infection.

Publication types

Comment

MeSH terms

Citrobacter rodentium*
Enterobacteriaceae Infections*
Humans
Intestinal Mucosa
Symbiosis