Compensating P. falciparum artemisinin resistance

Lucien Platon; Jun Cao; Didier Ménard

doi:10.1016/j.chom.2021.11.007

Compensating P. falciparum artemisinin resistance

Cell Host Microbe. 2021 Dec 8;29(12):1732-1734. doi: 10.1016/j.chom.2021.11.007.

Authors

Lucien Platon¹, Jun Cao², Didier Ménard³

Affiliations

¹ Malaria Genetics and Resistance Unit, INSERM U1201, Paris, France; ED515 Complexité du Vivant, Sorbonne Université, Paris, France.
² Jiangsu Institute of Parasitic Diseases, Wuxi, China; Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
³ Malaria Genetics and Resistance Unit, INSERM U1201, Paris, France; Institute of Parasitology and Tropical Diseases, UR7292 Dynamics of Host-Pathogen Interactions, Federation of Translational Medicine, University of Strasbourg, Strasbourg, France; Laboratory of Parasitology and Medical Mycology, Strasbourg University Hospital, Strasbourg, France. Electronic address: dmenard@unistra.fr.

PMID: 34883062
DOI: 10.1016/j.chom.2021.11.007

Abstract

Amino acid deprivation from reduced hemoglobin degradation in Pfkelch13 artemisinin-resistant parasites reduces fitness. In this issue of Cell Host & Microbe, Mesén-Ramírez et al. decipher the role of nutrient permeable channel activity within the parasitophorous vacuolar membrane to compensate for this fitness cost in asexual blood-stage Plasmodium falciparum parasites.

Publication types

Comment

MeSH terms

Antimalarials* / pharmacology
Artemisinins* / pharmacology
Drug Resistance
Mutation / drug effects
Plasmodium falciparum / drug effects
Plasmodium falciparum / genetics
Protozoan Proteins / genetics

Substances

Antimalarials
Artemisinins
Protozoan Proteins