Evaluation of the effect of extended refrigerated storage of serum and plasma specimens on syphilis serologic test results

Yongcheng Sun; Mayur R Shukla; John Deutsch; Weiping Cao; Yetunde Fakile; Ellen N Kersh; Lara E Pereira

doi:10.1016/j.diagmicrobio.2021.115588

Evaluation of the effect of extended refrigerated storage of serum and plasma specimens on syphilis serologic test results

Diagn Microbiol Infect Dis. 2022 Feb;102(2):115588. doi: 10.1016/j.diagmicrobio.2021.115588. Epub 2021 Oct 30.

Authors

Yongcheng Sun¹, Mayur R Shukla², John Deutsch³, Weiping Cao³, Yetunde Fakile¹, Ellen N Kersh¹, Lara E Pereira¹

Affiliations

¹ Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
² Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: iun9@cdc.gov.
³ Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA.

PMID: 34883351
DOI: 10.1016/j.diagmicrobio.2021.115588

Abstract

The effect of extended refrigerated storage of 14 serum and plasma specimens on 5 syphilis serologic tests was evaluated for 16 weeks. Higher stability of nontreponemal and treponemal antibodies in serum was recorded compared to plasma. Described work may provide insights on refrigerated specimens' stability and suitability for syphilis tests.

Keywords: Antibody; Nontreponemal; Stability; Syphilis; Treponemal.

Published by Elsevier Inc.

MeSH terms

Antibodies, Bacterial / analysis*
Antibodies, Bacterial / blood*
Humans
Plasma / microbiology
Refrigeration / methods*
Serum / microbiology
Specimen Handling / methods*
Syphilis / blood*
Syphilis / diagnosis*
Syphilis / microbiology*
Syphilis Serodiagnosis / methods*

Substances

Antibodies, Bacterial