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Review
. 2021 Nov 30;26(23):7266.
doi: 10.3390/molecules26237266.

Botanical, Phytochemical, Anti-Microbial and Pharmaceutical Characteristics of Hawthorn (Crataegusmonogyna Jacq.), Rosaceae

Federico Martinelli  1 , Anna Perrone  1 , Sanaz Yousefi  2 , Alessio Papini  1 , Stefano Castiglione  3 , Francesco Guarino  3 , Angela Cicatelli  3 , Mitra Aelaei  4 , Neda Arad  5 , Mansour Gholami  2 , Seyed Alireza Salami  6
Affiliations
Review

Botanical, Phytochemical, Anti-Microbial and Pharmaceutical Characteristics of Hawthorn (Crataegusmonogyna Jacq.), Rosaceae

Federico Martinelli et al. Molecules. .

Abstract

Hawthorn (Crataegus monogyna Jacq.) is a wild edible fruit tree of the genus Crataegus, one of the most interesting genera of the Rosaceae family. This review is the first to consider, all together, the pharmaceutical, phytochemical, functional and therapeutic properties of C. monogyna based on numerous valuable secondary metabolites, including flavonoids, vitamin C, glycoside, anthocyanin, saponin, tannin and antioxidants. Previous reviews dealt with the properties of all species of the entire genera. We highlight the multi-therapeutic role that C. monogyna extracts could have in the treatment of different chronic and degenerative diseases, mainly focusing on flavonoids. In the first part of this comprehensive review, we describe the main botanical characteristics and summarize the studies which have been performed on the morphological and genetic characterization of the C. monogyna germplasm. In the second part, the key metabolites and their nutritional and pharmaceutical properties are described. This work could be an essential resource for promoting future therapeutic formulations based on this natural and potent bioactive plant extract.

Keywords: Hawthorn; flavonoids; free radical scavenging; pharmaceutical; phytochemical.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The main phytochemical components of C. monogyna are divided into different principal classes.
Figure 2
Figure 2
Chemical structure of acids quantified in C. monogyna fruits, plants and flowers. (a) Phenolic acids; (b) flavonoids and glycosylates derivates in C. monogyna fruits, plants and flowers; (c) other flavonoids: epicatechin and procyanidin; (d) triterpenoid compounds.
Figure 2
Figure 2
Chemical structure of acids quantified in C. monogyna fruits, plants and flowers. (a) Phenolic acids; (b) flavonoids and glycosylates derivates in C. monogyna fruits, plants and flowers; (c) other flavonoids: epicatechin and procyanidin; (d) triterpenoid compounds.
Figure 2
Figure 2
Chemical structure of acids quantified in C. monogyna fruits, plants and flowers. (a) Phenolic acids; (b) flavonoids and glycosylates derivates in C. monogyna fruits, plants and flowers; (c) other flavonoids: epicatechin and procyanidin; (d) triterpenoid compounds.
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References

    1. Gundogdu M., Ozrenk K., Ercisli S., Kan T., Kodad O., Hegedus A. Organic acids, sugars, vitamin C content and some pomological characteristics of eleven hawthorn species (Crataegus spp.) from Turkey. Biol. Res. 2014;47:1–5. doi: 10.1186/0717-6287-47-21. - DOI - PMC - PubMed
    1. Phipps J.B. Crataegus—A nomenclator for sectional and serial names. Taxon. 1983;32:598–604. doi: 10.2307/1221729. - DOI
    1. Phipps J.B., Robertson K.R., Rohrer J.R., Smith P.G. Origins and Evolution of Subfam. Maloideae (Rosaceae) Syst. Botany. 1991;16:303. doi: 10.2307/2419283. - DOI
    1. Campbell C.S., Dickinson T.A. Apomixis, Patterns of Morphological Variation, and Species Concepts in subfam. Maloideae (Rosaceae) Syst. Botany. 1990;15:124. doi: 10.2307/2419022. - DOI
    1. Christensen K.I. Revision of Crataegus Sect. Crataegus and Nothosect. Crataeguineae (Rosaceae-Maloideae) in the Old World. Syst. Botany Monogr. 1992;35:1. doi: 10.2307/25027810. - DOI

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