Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms

doi:10.1038/s41569-021-00662-w

. 2022 Feb;19(2):75-77.

doi: 10.1038/s41569-021-00662-w.

Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms

Stephane Heymans¹, Leslie T Cooper²

Affiliations

¹ Maastricht University Medical Centre, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, Netherlands. s.heymans@maastrichtuniversity.nl.
² Department of Cardiovascular Medicine, Mayo Clinic in Florida, Jacksonville, FL, USA.

PMID: 34887571
PMCID: PMC8656440
DOI: 10.1038/s41569-021-00662-w

Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms

Stephane Heymans et al. Nat Rev Cardiol. 2022 Feb.

. 2022 Feb;19(2):75-77.

doi: 10.1038/s41569-021-00662-w.

Authors

Stephane Heymans¹, Leslie T Cooper²

Affiliations

¹ Maastricht University Medical Centre, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, Netherlands. s.heymans@maastrichtuniversity.nl.
² Department of Cardiovascular Medicine, Mayo Clinic in Florida, Jacksonville, FL, USA.

PMID: 34887571
PMCID: PMC8656440
DOI: 10.1038/s41569-021-00662-w

Erratum in

Author Correction: Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms.
Heymans S, Cooper LT. Heymans S, et al. Nat Rev Cardiol. 2023 Aug;20(8):575. doi: 10.1038/s41569-023-00904-z. Nat Rev Cardiol. 2023. PMID: 37344581 Free PMC article. No abstract available.

Abstract

The risk of acute myocarditis associated with COVID-19 mRNA vaccination has garnered intense (social) media attention. However, myocarditis after COVID-19 mRNA vaccination is rare and usually resolves within days or weeks. Moreover, the risks of hospitalization and death associated with COVID-19 are greater than the risk associated with COVID-19 vaccination. Therefore, COVID-19 vaccination should be recommended in adolescents and adults.

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Conflict of interest statement

The authors declare no competing interests.

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References

1. Heymans S, Eriksson U, Lehtonen J, Cooper LT., Jr The quest for new approaches in myocarditis and inflammatory cardiomyopathy. J. Am. Coll. Cardiol. 2016;68:2348–2364. doi: 10.1016/j.jacc.2016.09.937. - DOI - PubMed
1. Witberg G, et al. Myocarditis after Covid-19 vaccination in a large health care organization. N. Engl. J. Med. 2021 doi: 10.1056/NEJMoa2110737. - DOI - PMC - PubMed
1. Mevorach D, et al. Myocarditis after BNT162b2 mRNA vaccine against Covid-19 in Israel. N. Engl. J. Med. 2021 doi: 10.1056/NEJMoa2109730. - DOI - PMC - PubMed
1. Klein NP, et al. Surveillance for adverse events after COVID-19 mRNA vaccination. JAMA. 2021;326:1390–1399. doi: 10.1001/jama.2021.15072. - DOI - PMC - PubMed
1. Montgomery J, et al. Myocarditis following immunization with mRNA COVID-19 vaccines in members of the US Military. JAMA Cardiol. 2021;6:1202–1206. doi: 10.1001/jamacardio.2021.2833. - DOI - PMC - PubMed

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[1] Heymans S, Eriksson U, Lehtonen J, Cooper LT., Jr The quest for new approaches in myocarditis and inflammatory cardiomyopathy. J. Am. Coll. Cardiol. 2016;68:2348–2364. doi: 10.1016/j.jacc.2016.09.937. - DOI - PubMed

[2] Heymans S, Eriksson U, Lehtonen J, Cooper LT., Jr The quest for new approaches in myocarditis and inflammatory cardiomyopathy. J. Am. Coll. Cardiol. 2016;68:2348–2364. doi: 10.1016/j.jacc.2016.09.937. - DOI - PubMed

[3] Witberg G, et al. Myocarditis after Covid-19 vaccination in a large health care organization. N. Engl. J. Med. 2021 doi: 10.1056/NEJMoa2110737. - DOI - PMC - PubMed

[4] Witberg G, et al. Myocarditis after Covid-19 vaccination in a large health care organization. N. Engl. J. Med. 2021 doi: 10.1056/NEJMoa2110737. - DOI - PMC - PubMed

[5] Mevorach D, et al. Myocarditis after BNT162b2 mRNA vaccine against Covid-19 in Israel. N. Engl. J. Med. 2021 doi: 10.1056/NEJMoa2109730. - DOI - PMC - PubMed

[6] Mevorach D, et al. Myocarditis after BNT162b2 mRNA vaccine against Covid-19 in Israel. N. Engl. J. Med. 2021 doi: 10.1056/NEJMoa2109730. - DOI - PMC - PubMed

[7] Klein NP, et al. Surveillance for adverse events after COVID-19 mRNA vaccination. JAMA. 2021;326:1390–1399. doi: 10.1001/jama.2021.15072. - DOI - PMC - PubMed

[8] Klein NP, et al. Surveillance for adverse events after COVID-19 mRNA vaccination. JAMA. 2021;326:1390–1399. doi: 10.1001/jama.2021.15072. - DOI - PMC - PubMed

[9] Montgomery J, et al. Myocarditis following immunization with mRNA COVID-19 vaccines in members of the US Military. JAMA Cardiol. 2021;6:1202–1206. doi: 10.1001/jamacardio.2021.2833. - DOI - PMC - PubMed

[10] Montgomery J, et al. Myocarditis following immunization with mRNA COVID-19 vaccines in members of the US Military. JAMA Cardiol. 2021;6:1202–1206. doi: 10.1001/jamacardio.2021.2833. - DOI - PMC - PubMed

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Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms

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Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms

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