Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms

Nat Rev Cardiol. 2022 Feb;19(2):75-77. doi: 10.1038/s41569-021-00662-w.


The risk of acute myocarditis associated with COVID-19 mRNA vaccination has garnered intense (social) media attention. However, myocarditis after COVID-19 mRNA vaccination is rare and usually resolves within days or weeks. Moreover, the risks of hospitalization and death associated with COVID-19 are greater than the risk associated with COVID-19 vaccination. Therefore, COVID-19 vaccination should be recommended in adolescents and adults.

MeSH terms

  • COVID-19 Vaccines* / administration & dosage
  • COVID-19 Vaccines* / adverse effects
  • Humans
  • Myocarditis* / epidemiology
  • Vaccines, Synthetic* / administration & dosage
  • Vaccines, Synthetic* / adverse effects
  • mRNA Vaccines* / administration & dosage
  • mRNA Vaccines* / adverse effects


  • COVID-19 Vaccines
  • Vaccines, Synthetic
  • mRNA Vaccines