Attenuation of actinic prurigo eruptions with Polypodium leucotomos supplementation

Pediatr Dermatol. 2022 Jan;39(1):145-146. doi: 10.1111/pde.14876. Epub 2021 Dec 9.


Actinic prurigo is a rare pruritic photodermatosis. We report the use of Polypodium leucotomos extract in an 11-year-old female patient with actinic prurigo, resulting in a significant attenuation of her disease without development of adverse effects to date. Polypodium leucotomos exerts a pleiotropic immunomodulatory and antioxidant effect by shifting the balance from pro- to an antiinflammatory cytokine environment. This counteracts the effects of UV-induced cellular damage characteristic of photodermatoses.

Publication types

  • Case Reports

MeSH terms

  • Antioxidants
  • Child
  • Dietary Supplements
  • Female
  • Humans
  • Photosensitivity Disorders
  • Plant Extracts / therapeutic use
  • Polypodium*
  • Prurigo* / drug therapy
  • Skin Diseases, Genetic


  • Antioxidants
  • Plant Extracts

Supplementary concepts

  • Actinic Prurigo