The paper proposes accurate Blood Pressure Monitoring (BPM) based on a single-site Photoplethysmographic (PPG) sensor and provides an energy-efficient solution on edge cuffless wearable devices. Continuous PPG signal preprocessed and used as input of the Artificial Neural Network (ANN), and outputs systolic BP (SBP), diastolic BP (DBP), and mean arterial BP (MAP) values for each heartbeat. The improvement of the BPM accuracy is obtained by removing outliers in the preprocessing step and the whole-based inputs compared to parameter-based inputs extracted from the PPG signal. Performance obtained is 3.42 ± 5.42 mmHg (MAE ± RMSD) for SBP, 1.92 ± 3.29 mmHg for DBP, and 2.21 ± 3.50 mmHg for MAP which is competitive compared to other studies. This is the first BPM solution with edge computing artificial intelligence as we have learned so far. Evaluation experiments on real hardware show that the solution takes 42.2 ms, 18.2 KB RAM, and 2.1 mJ average energy per reading.