A lumped parameter synergistic model of the human cardiovascular system (CVS) is proposed to integrate the heart's electrical activity with its mechanical activity. This model can represent the physiological condition of a patient in an effective way, whether it is considered normal or with some cardiac disorders. The electrical activity is coupled to the CVS model through electrocardiogram (ECG) signals in the suggested model. The variations in ECG morphology are detected by appropriate algorithms and changes parameters of the CVS model, such as systemic resistance and end-systolic pressure-volume relationship.Clinical relevance- It provides interpretation and analysis of physiological data of the cardiovascular system, both of electrical and mechanical cardiac behavior, evaluated together.