Characterization of dispersion and anisotropic-conductivity in tissue model during electroporation pulses

Abstract

Electroporation occurs when biological cells are exposed to intensive, short-duration pulses, which can be used to ablate biological tumor tissues. Based on the traditional numerical models, the isotropic conductivity model with the non-dispersion effect (ICND), the anisotropic conductivity model with the dispersion effect (ACD) is developed in this study. The second-order Debye function is introduced to manifest the dielectric relaxation effect, and the two-dimensional Cartesian conductivity matrix is applied to describe the anisotropy of the tissue conductivity during the electroporation process. A monopolar pulse and a monopolar burst are applied to the breast tumor model through the two-needle electrodes configuration. The results show that taking the dispersion into account can increase the total electroporated area more than 2.31%. Considering the conductivity anisotropy, the total electroporated area increases, but the irreversible electroporation (IRE) area decreases by more than 3.99%. The ACD model can achieve a larger electroporated area but a relatively smaller IRE area than those of the ICND model, and comparably minor maximum thermal damage is evaluated in the ACD model. Our model analyzes the effects of the dielectric dispersion and anisotropic conductivity of tissue, which have strong guiding significance for making the treatment planning before clinical practice.

Keywords: Anisotropic conductivity; Breast tumor; Debye fuction; Dispersion effect; Electroporation.