Vestibular and postural impairment in congenital Cytomegalovirus infection

Int J Pediatr Otorhinolaryngol. 2022 Jan:152:111005. doi: 10.1016/j.ijporl.2021.111005. Epub 2021 Dec 7.


Objectives: To describe the vestibular and postural impairment related to the congenital Cytomegalovirus infection (cCMV), including the inner ear damages CMV-induced.

Methods: A PRISMA systematic review was performed, with the PubMed, Embase, and Cinahl databases searched from inception through to March 2021; after the application of inclusion and exclusion criteria a total of 12 papers were included in this review.

Results: Vestibular and postural disorders have been reported in cCMV children, with a high variability of clinical manifestation. Presently, the available reported data on vestibular and postural impairment in cCMV children differ in terms of the sample size and the features of the studied populations.

Conclusion: At present, the vestibular and postural impairment in cCMV cases is underestimated; a complete vestibular assessment, a follow-up and management of all children affected by cCMV or, at least, of all cCMV patients showing sensorineural hearing loss, is recommended.

Keywords: Child; Congenital cytomegalovirus infection; Inner ear; Newborn; Postural impairment; Vestibular impairment.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Child
  • Cytomegalovirus Infections* / complications
  • Hearing Loss, Sensorineural* / diagnosis
  • Hearing Loss, Sensorineural* / etiology
  • Humans
  • Vestibule, Labyrinth*