Gut microbiome and its role in colorectal cancer

BMC Cancer. 2021 Dec 11;21(1):1325. doi: 10.1186/s12885-021-09054-2.


Colorectal cancer (CRC) is still one of the most common types of cancer in the world, and the gut microbiome plays an important role in its development. The microbiome is involved in the carcinogenesis, formation and progression of CRC as well as its response to different systemic therapies. The composition of bacterial strains and the influence of geography, race, sex, and diet on the composition of the microbiome serve as important information for screening, early detection and prediction of the treatment outcome of CRC.Microbiome modulation is one of the most prospective new strategies in medicine to improve the health of individuals. Therefore, future research and clinical trials on the gut microbiome in oncology as well as in the treatment of CRC patients are warranted to determine the efficacy of systemic treatments for CRC, minimize adverse effects and increase survival rates.

Keywords: Colorectal cancer; Gut microbiome; Modulation of gut microbiome; Prognostic and predictive biomarkers; Systemic treatment of CRC.

Publication types

  • Review

MeSH terms

  • Colorectal Neoplasms*
  • Dysbiosis*
  • Gastrointestinal Microbiome*
  • Humans