hsa_circ_0072389, hsa_circ_0072386, hsa_circ_0008621, hsa_circ_0072387, and hsa_circ_0072391 aggravate glioma via miR-338-5p/IKBIP

Aging (Albany NY). 2021 Dec 12;13(23):25213-25240. doi: 10.18632/aging.203740. Epub 2021 Dec 12.

Abstract

Glioma is a primary intracranial tumor with high morbidity and mortality. We acquired miR-338-5p, which suppresses the development of glioma, from the GEO and CGGA databases. In addition, we predicted that hsa_circ_0072389, hsa_circ_0072386, hsa_circ_0008621, hsa_circ_0072387, and hsa_circ_0072391 could relieve the silencing of IKBIP by miR-338-5p. By analyzing genes related to IKBIP expression, possible pathways affecting glioma were identified. This study provides new ideas for investigating multiple circRNAs in ceRNAs.

Keywords: IKBIP; ceRNA; circRNA; glioma; miR-338-5p.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blotting, Western
  • Brain Neoplasms / metabolism*
  • Brain Neoplasms / pathology
  • Cell Line, Tumor
  • Glioma / metabolism*
  • Glioma / pathology
  • Humans
  • MicroRNAs / metabolism*
  • RNA, Circular / metabolism*
  • Signal Transduction

Substances

  • MIRN338 microRNA, human
  • MicroRNAs
  • RNA, Circular