The evolution of adjuvant/neoadjuvant trials for resectable localized sarcoma

J Surg Oncol. 2022 Jan;125(1):17-27. doi: 10.1002/jso.26745.


Soft-tissue sarcomas are rare tumors arising from mesenchymal tissues. As a heterogeneous group comprising more than 50 types, the development of clinical trials remains challenging. Decision-making for neoadjuvant or adjuvant chemotherapy and radiation therapy is based on the available evidence of contemporary trials and multidisciplinary clinical judgment.

Keywords: chemotherapy; clinical trials; extremity sarcoma; immunotherapy; radiotherapy; retroperitoneal sarcoma.

Publication types

  • Review

MeSH terms

  • Chemotherapy, Adjuvant
  • Clinical Trials, Phase II as Topic / methods*
  • Clinical Trials, Phase III as Topic / methods*
  • Humans
  • Neoadjuvant Therapy
  • Radiotherapy, Adjuvant
  • Randomized Controlled Trials as Topic / methods
  • Sarcoma / therapy*
  • Soft Tissue Neoplasms / therapy*