Excretion and Residual Concentration Correlations of Salbutamol Between Edible Tissues and Living Samples in Pigs and Goats

Lei Sun; Minjuan Zhu; Jingfei Shi; Kun Mi; Wenjing Ma; Xiangyue Xu; Hanyu Wang; Yuanhu Pan; Yanfei Tao; Zhenli Liu; Lingli Huang

doi:10.3389/fphar.2021.754876

Excretion and Residual Concentration Correlations of Salbutamol Between Edible Tissues and Living Samples in Pigs and Goats

Front Pharmacol. 2021 Nov 25:12:754876. doi: 10.3389/fphar.2021.754876. eCollection 2021.

Authors

Lei Sun^{1

2

3}, Minjuan Zhu^{1

2

3}, Jingfei Shi^{1

2

3}, Kun Mi^{1

2}, Wenjing Ma^{1

2

3}, Xiangyue Xu^{1

2

3}, Hanyu Wang^{1

2

3}, Yuanhu Pan^{1

2

3}, Yanfei Tao^{1

2

3}, Zhenli Liu^{1

2

3}, Lingli Huang^{1

2

3}

Affiliations

¹ MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Wuhan, China.
² National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan, China.
³ College of Veterinary Medicine of Huazhong Agricultural University, Wuhan, China.

Abstract

Illegal use of salbutamol (SAL), a β-adrenergic leanness-enhancing agent, has posed potential threat to human health in China. The excretion and depletion of SAL in pigs and goats were investigated, and the concentration correlations between edible tissues and living samples were analyzed to find out a suitable living sample for pre-slaughter monitoring of SAL in pigs and goats. After a single oral dosage of 1.2 mg/kg SAL, approximately 70% of the dose was excreted by pigs and goats from their excreta. When pigs and goats were supplied feed containing SAL (20 mg/kg) for 14 consecutive days, high concentrations of SAL were observed in the liver and kidneys, and the longest persistence was observed in hair. Unlike pigs, SAL was presented primarily as conjugated SAL in goats. Excellent concentration correlations of SAL were observed between urine and edible tissues both in pigs and goats, and in addition, good correlations also were found between hair and edible tissues in pigs and between feces and edible tissues in goats. Hence, urine and hair could accurately predict SAL concentrations in edible tissues of pigs, whereas feces and urine were satisfactory for predicting SAL concentrations in edible tissues of goats. These data make it possible for pre-slaughter monitoring of SAL residues in the edible tissues of pigs and goats.

Keywords: SAL; depletion; excretion; goat; pig; pre-slaughter monitoring.