Unsupervised Algorithms for Microarray Sample Stratification

Methods Mol Biol. 2022;2401:121-146. doi: 10.1007/978-1-0716-1839-4_9.


The amount of data made available by microarrays gives researchers the opportunity to delve into the complexity of biological systems. However, the noisy and extremely high-dimensional nature of this kind of data poses significant challenges. Microarrays allow for the parallel measurement of thousands of molecular objects spanning different layers of interactions. In order to be able to discover hidden patterns, the most disparate analytical techniques have been proposed. Here, we describe the basic methodologies to approach the analysis of microarray datasets that focus on the task of (sub)group discovery.

Keywords: Clustering; Dimensionality reduction; Group discovery; Microarray; Unsupervised learning.

MeSH terms

  • Algorithms*
  • Cluster Analysis
  • Gene Expression Profiling
  • Oligonucleotide Array Sequence Analysis