Sensitivity enhancement in capillary electrophoresis and their applications for analyses of pharmaceutical and related biochemical substances

L Suntornsuk; O Anurukvorakun

doi:10.1002/elps.202100236

Sensitivity enhancement in capillary electrophoresis and their applications for analyses of pharmaceutical and related biochemical substances

Electrophoresis. 2022 May;43(9-10):939-954. doi: 10.1002/elps.202100236. Epub 2022 Jan 19.

Authors

L Suntornsuk¹, O Anurukvorakun²

Affiliations

¹ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
² Department of Cosmetic Science, Phranakorn Rajabhat University, Bangkok, Thailand.

PMID: 34902168
DOI: 10.1002/elps.202100236

Abstract

This review aims to illustrate sensitivity enhancement methods in capillary electrophoresis (CE) and their applications for pharmaceutical and related biochemical substance analyses. The first two parts of the article describe the introduction and principle of CE. The main part focuses on strategies for sensitivity improvement in CE including detector and capillary technologies and preconcentration techniques. Applications of these techniques for pharmaceutical and biomedical substance analyses are surveyed during the years 2018-2021.

Keywords: Biochemical substances; Capillary electrophoresis; Pharmaceutical; Sensitivity enhancement.

Publication types

Review

MeSH terms

Electrophoresis, Capillary* / methods
Pharmaceutical Preparations

Substances

Pharmaceutical Preparations